Regulatory Toxicology and Pharmacology
نویسندگان
چکیده
The Agency for Toxic Substances and Disease Reg istry (ATSDR) derives minimal risk levels (MRLs) to assist in evaluating risk of adverse health effects in individuals exposed to hazardous substances. MRLs are derived from published values identifying no-ob served-adverse-effect levels (NOAELs) or lowest-ob served-adverse-effect levels (LOAELs) in animal or hu man studies. The most sensitive end points are used. To date, 4 inhalation MRLs and 13 oral MRLs have been derived from hematological end points for 12 substances. This paper provides a brief overview of the hematological system, examples of hematological end points, and the MRL for substances with hemato logical end points.
منابع مشابه
Comments on the safety assessment of decamethylcyclopentasiloxane (D5) published in regulatory toxicology and pharmacology, 2017, 83:117-118.
This letter is in response to the summary of the safety assessment of the Scientific Committee on Consumer Safety (SCCS) on decamethylcyclopentasiloxane (D5) in cosmetic products published (SCCS & Rousselle, 2017) and the opinion (SCCS, 2017). We have been asked by the Silicones Environmental, Health and Safety Center of the American Chemistry Council to provide comments given that SCCS (2017) ...
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